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Thymosin Alpha-1

♢ Research use only Class-level spec; selected lots Janoshik-tested

✓ Janoshik Verified 99.631%Thymosin Alpha-1 5mg · Report #212159 ↗
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Thymosin Alpha-1 is a 28-amino acid immunomodulatory peptide originally isolated from thymic tissue. It has been extensively studied for its role in modulating innate and adaptive immune responses in various research models.

  • 28-amino acid thymic peptide
  • Innate and adaptive immune modulation research
  • Dendritic cell maturation and T-cell activation studies

For research purposes only.

About Thymosin Alpha-1

About Thymosin Alpha-1

Thymosin Alpha-1 (CAS: 62304-98-7) is a naturally occurring 28-amino acid peptide first isolated from thymosin fraction 5, a preparation derived from bovine thymus tissue. It is an N-terminally acetylated peptide that plays a central role in immune system maturation and regulation. Thymosin Alpha-1 has been one of the most extensively studied thymic peptides, with research spanning several decades across immunology and infectious-disease research fields.

Mechanism of Action

Thymosin Alpha-1 acts as a biological response modifier, enhancing immune function through multiple pathways. It promotes the differentiation and maturation of dendritic cells, enhancing their antigen-presenting capacity. The peptide stimulates T-cell maturation from progenitor cells via upregulation of T-cell surface markers. It modulates cytokine production, shifting the balance toward Th1 responses, and activates natural killer (NK) cell cytotoxicity. Additionally, Thymosin Alpha-1 signals through Toll-like receptors (TLR-2 and TLR-9) on myeloid and plasmacytoid dendritic cells.

Published Research

  • Romani, L., et al. (2007). Thymosin Alpha-1: an endogenous regulator of inflammation, immunity, and tolerance. Clinical Immunology. DOI: 10.1016/j.clim.2006.11.010
  • Wu, M., et al. (2020). Thymosin Alpha-1 as an immunomodulatory agent in sepsis management. Annals of Intensive Care. DOI: 10.1186/s13613-020-00710-3

Product Specifications

  • Molecular Weight: 3108.3 Da
  • CAS Number: 62304-98-7
  • Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN (28-AA)
  • Purity: ≥98% (class-level specification)
  • Form: Lyophilized powder
  • Storage: -20°C, protected from light

Selected lots independently tested by Janoshik Analytical: search by batch or report code

This product is intended for research purposes only. Not for human consumption. CertaPeptides does not condone or encourage any off-label use.

Researcher Confidence

Why researchers choose CertaPeptides

Who actually tests this?

Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.

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What if I get the wrong batch?

Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.

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Where does it ship from?

Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.

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What if there's a problem?

You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@chinapeptideshop.com.

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Product Information

This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.

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