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Epitalon

♢ Research use only Class-level spec; selected lots Janoshik-tested

✓ Janoshik Verified 99.514%Epitalon 50mg · Report #233662 ↗
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Epitalon is a 4-amino acid synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase activation and telomere biology research. Derived from pineal gland epithalamin. Class-level specification ≥98%; selected lots independently tested.

Key research areas:

  • Telomerase reactivation and telomere elongation in somatic cells
  • Pineal gland neuroendocrine function and melatonin regulation
  • Cellular aging and geroprotective mechanisms

For research purposes only. Not for human consumption.

About Epitalon

About Epitalon

Epitalon (CAS 307297-39-8), also known as Epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). It was synthesized based on the amino acid composition of epithalamin, a polypeptide extract derived from the bovine pineal gland. Over 25 years of published research have characterized its telomere-related, neuroendocrine, and antioxidant properties in both in vitro and in vivo models.

Mechanism of Action

Epitalon has been shown to reactivate the catalytic subunit of telomerase (hTERT) in telomerase-negative human somatic cells, leading to measurable telomere elongation. Research demonstrates dose-dependent telomere length extension through both telomerase upregulation and alternative lengthening of telomeres pathways. Additionally, epitalon modulates pineal gland function by upregulating melatonin biosynthesis enzymes, restoring circadian melatonin rhythms that decline with age.

Published Research

  • Telomerase induction: Epitalon reactivated telomerase gene expression and enzymatic activity in human fetal fibroblast cultures, inducing telomere elongation in cells that normally lack telomerase. (DOI)
  • Neuroendocrine restoration: Administration to aged rhesus monkeys restored nighttime melatonin levels, reduced basal glucose and insulin. (DOI)
  • Comprehensive bioactivity: A systematic review confirmed significant telomere-related and neuroendocrine effects originating from antioxidant, neurotrophic, and antimutagenic activity. (DOI)

Product Specifications

  • Purity: ≥98% (class-level specification)
  • Form: Lyophilized powder
  • CAS: 307297-39-8
  • Molecular Weight: 390.3 Da

Class-level specification ≥98%; selected lots are independently tested by Janoshik Analytical, searchable by batch or report code at certapeptides.com/verify. Verify a batch →

For research purposes only. Not for human consumption.

What research shows

Selected peer-reviewed studies from the published literature. Each describes laboratory or preclinical findings and is attributed to the cited study, not to this product. For research purposes only — not medical guidance.

[1]

Telomerase and telomere biology

In cell-culture studies of human somatic cells, Epitalon (Epithalon) was reported to induce telomerase activity and telomere elongation.

Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine (2003). PMID: 12937682
[2]

Pineal gland and melatonin

In pinealocyte cell-culture research, Epitalon-type pineal peptides were examined for molecular-cellular mechanisms regulating melatonin synthesis.

Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. Bulletin of Experimental Biology and Medicine (2012). PMID: 22816096

Citations are provided for research reference. CertaPeptides (CERTALAB S.R.L.) is a reseller, not a manufacturer, and makes no medical, therapeutic, or efficacy claims. Products are for research purposes only and are not for human or animal consumption.

Researcher Confidence

Why researchers choose CertaPeptides

Who actually tests this?

Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.

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What if I get the wrong batch?

Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.

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Where does it ship from?

Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.

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What if there's a problem?

You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@chinapeptideshop.com.

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Product Information

This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.

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