Om Semax + Selank Blend 20mg
Semax + Selank Blend combines two Russian-developed nootropic peptides with different but complementary mechanisms in a single vial (10mg each, 20mg total). Both were developed by the Institute of Molecular Genetics of the Russian Academy of Sciences and have an unusually long research history in Russia and Eastern Europe — a distinction that provides some pharmacology data, even if that literature predates modern trial standards.
Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence (methionine-glutamate-histidine-phenylalanine) with a proline-glycine-proline extension that increases its stability and bioactivity. In research models it is studied for its role in BDNF and NGF pathways — upregulating brain-derived and nerve growth factors. Research effects include neuroprotection, acetylcholinergic and neuropeptidergic receptor binding in memory consolidation models, and attention-related parameters. Semax has been studied in models of ischemic injury, which provides some translational context, though the evidence base is not equivalent to Western Phase III trial standards.
Selank is derived from tuftsin, an endogenous immunoregulatory peptide. In research models it is studied for its interaction with the GABA system, including a GABA-B receptor component. Selank has also been studied for immunomodulatory activity, including stress-induced immune suppression in animal models.
The combination addresses both acetylcholinergic and neuropeptidergic receptor binding (Semax) and GABA-system and immunomodulatory signalling (Selank) — complementary rather than redundant mechanisms in the context of cognitive performance research.
Specifications
| Parameter |
Value |
| Component 1 |
Semax 10mg (ACTH(4-7) derivative) |
| Component 2 |
Selank 10mg (Tuftsin analogue) |
| Total per Vial |
20mg combined |
| Renhet |
No single figure (multi-peptide blend) |
| Format |
Lyophilized powder, single-use vial |
| Förvaring |
-20°C before reconstitution; 2-8°C after |
Förvaring
Store at -20°C before reconstitution. Refrigerate at 2-8°C after reconstitution. No blend-specific use window is published once mixed. Both peptides are stable under proper conditions but should be protected from light and heat.
What is the mechanism of Semax as a nootropic?
Semax is derived from the ACTH(4-7) sequence — the minimal active fragment of adrenocorticotropic hormone — modified for stability. Its primary documented mechanisms in research models involve upregulation of BDNF and NGF, neurotrophins that support neuronal survival, plasticity, and function. In rodent models it enhances learning, memory consolidation, and attention-related parameters. It also has documented neuroprotective effects in ischemia models, which is an active area of preclinical research.
How is Selank studied in research models?
Selank is studied in rodent models for its interaction with the GABA system, including GABA-B components, and for its immunomodulatory activity.
In what form is this blend supplied?
Semax and Selank are supplied together as a lyophilized blend in a single vial, for reconstitution in laboratory research only.
Semax + Selank Blend is supplied for research purposes only. Not for human use. Handle in compliance with institutional biosafety guidelines.