Acetic Acid Water 10ml

Acetic acid water (0.6% acetic acid in USP-grade water for injection, per the specification on record) is an alternative reconstitution medium for research peptides that are poorly soluble in neutral aqueous solutions. At physiological pH, many cationic peptides — particularly those rich in arginine and lysine — form aggregates through intermolecular electrostatic and hydrophobic interactions. Lowering the pH protonates more amino groups, increases electrostatic repulsion between peptide chains, and disrupts aggregation, producing a clear, stable solution that can then be diluted into higher-pH buffers for experimental use.

When to Use Acetic Acid Water

The protocol is typically: dissolve in acetic acid water first to produce a concentrated stock, then dilute into PBS, saline, or media for the working solution.

Do not use acetic acid reconstitution for peptides with acid-sensitive bonds — aspartyl-proline sequences and some modified peptides can undergo acid hydrolysis. Also avoid for experiments where a precisely controlled pH is critical to the readout. For standard peptide solubilization where your primary concern is getting the compound into solution, dilute acetic acid is a well-established approach that the peptide research community has used for decades.

Specifications

Skladování

Store at room temperature, away from heat sources and direct sunlight. Acetic acid water does not require refrigeration before opening. Once opened and added to a peptide vial, store reconstituted solution at 4°C — acetic acid water lacks the benzyl alcohol preservative of bacteriostatic water, so the stability window is shorter.

Acetic acid water is supplied for laboratory research. For research purposes only.