MOTS-c

Tietoja: MOTS-c

About MOTS-c

What is MOTS-c?
Here is something that should not exist according to the central dogma: a peptide encoded in mitochondrial DNA that leaves the mitochondria, travels to the nucleus, and directly regulates gene expression. MOTS-c is a 16-amino-acid mitochondrial-derived peptide discovered by Changhan David Lee at USC in 2015, and it acts as a retrograde signal — information flowing from the organelle to the genome, backwards from what textbooks describe.

CAS: 1627580-64-6. MOTS-c is a mitochondrial-derived peptide studied in laboratory models of AMPK signalling.

Mechanism of Action

Why it is interesting
Two things. First, the retrograde signaling: MOTS-c is encoded in mitochondrial 12S rRNA, not the nuclear genome. Under metabolic stress, it translocates to the nucleus and directly regulates transcription. This means mitochondria are not just energy factories — they signal to the nucleus, adjusting metabolic gene expression.

Second, AMPK signalling. In laboratory models, MOTS-c is reported to activate AMPK by inhibiting de novo purine synthesis.

Research Overview

Säilytys
Lyophilized at -20°C. Reconstituted: 2-8°C.

Laatu
Class-level specification ≥98%; selected lots are independently tested by Janoshik Analytical, searchable by batch or report code at certapeptides.com/verify. Sold and shipped from the EU by CERTALAB S.R.L.

Product Specifications

• Molecular weight: 2,174.6 Da
• CAS: 1627580-64-6
• Purity: ≥98% (class-level specification)
• Muoto: Lyophilized powder
• SKU: CP-MOT

Selected lots independently tested by Janoshik Analytical, searchable by batch or report code. View reports →

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