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Semax

♢ Research use only Class-level spec; selected lots Janoshik-tested

✓ Janoshik Verified 98.550%Semax 5mg · Report #155232 ↗
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Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone fragment ACTH(4-7). It has been studied extensively for its neurotrophic and nootropic properties in various experimental models.

  • ACTH(4-7) analog with enhanced metabolic stability
  • Neurotrophic factor expression and BDNF pathway research
  • CNS receptor binding markers and memory research models

For research purposes only. Not for human consumption.

Description

About Semax

Semax (CAS: 80714-61-0) is a synthetic heptapeptide derived from the ACTH(4-7) fragment (Met-Glu-His-Phe) with an appended Pro-Gly-Pro tripeptide sequence to enhance metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax retains the neurotrophic properties of the parent ACTH fragment while resisting rapid enzymatic degradation.

Mechanism of Action

Semax influences multiple neurotransmitter systems and neurotrophic pathways. It has been shown to upregulate brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in experimental models. The peptide modulates dopaminergic, serotonergic, and cholinergic neurotransmission. Research also indicates effects on gene expression patterns related to neuronal survival and plasticity, involving activation of signaling cascades including the MAPK/ERK pathway.

Published Research

  • Gusev, E. I., et al. (2006). Neurotrophic effects of Semax in experimental cerebral ischemia models. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-006-0034-0
  • Eremin, K. O., et al. (2008). Semax effects on cognitive processes and neurotransmitter systems. Neuroscience and Behavioral Physiology. DOI: 10.1007/s11055-008-0037-y

Product Specifications

  • Molecular Weight: 813.9 Da
  • CAS Number: 80714-61-0
  • Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH(4-7) analog)
  • Purity: ≥98% (class-level specification)
  • Form: Lyophilized powder
  • Storage: -20°C, protected from light

Class-level specification ≥98%; selected lots are independently tested by Janoshik Analytical, searchable by batch or report code at certapeptides.com/verify.

For research purposes only. Not for human consumption.

Size

10mg, 30mg, 5mg

Consult the published report for lot-specific measured results.

Semax 10mg

Semax 10mg · Result: 99.477% · Measured content: 10.93 mg (109.3% of label) · Report Code: F48S54Y1HAYQ · Test Date: 2026-08-06 · Lab: Janoshik Analytical

View independent report #212155 ↗

Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.

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