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SS-31

♢ Research use only Class-level spec; selected lots Janoshik-tested

✓ Janoshik Verified 99.841%SS-31 10mg · Report #212156 ↗
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Research-grade SS-31. Class-level specification ≥98%; selected lots independently tested. Lyophilized powder in sealed glass vial. For research purposes only. Not for human consumption.

Description

About SS-31

What is SS-31?
Most antioxidants float around the cytoplasm and scavenge free radicals after they have already been produced. SS-31 goes to where the radicals are made. It concentrates about 1,000-fold in the inner mitochondrial membrane, binds cardiolipin — a phospholipid found only in mitochondria — and stabilizes the electron transport chain so fewer radicals get produced in the first place. Prevention, not cleanup.

CAS: 736992-21-5. Also called elamipretide, Bendavia, and MTP-131. Multiple preclinical and experimental studies have been conducted in the context of Barth syndrome, cardiac biology, and renal biology.

Mechanism of Action

The cardiolipin angle
Cardiolipin is unique to mitochondrial inner membranes. It holds cytochrome c in the right position for efficient electron transfer. When cardiolipin gets oxidized (which happens during aging and in various biological conditions), the electron transport chain becomes sloppy — electrons leak, produce superoxide, damage more cardiolipin, and the cycle accelerates. SS-31 breaks that cycle by stabilizing the cardiolipin-cytochrome c interaction.

Mechanism
The D-Arg-Dmt-Lys-Phe-NH2 sequence has alternating aromatic and cationic residues that drive 1,000-fold mitochondrial accumulation. Once there, it binds cardiolipin, optimizes cytochrome c interaction, reduces electron leak, lowers superoxide production, and maintains ATP output under stress. It also prevents mitochondrial permeability transition pore opening during ischemia-reperfusion — which is why it is studied in cardiac and renal research models.

Research Overview

Experimental interest is significant: Barth syndrome is a genetic cardiolipin deficiency, and SS-31 has been extensively studied in the context of this condition.

Research context
Mitochondrial dysfunction and bioenergetics. Ischemia-reperfusion research (heart, kidney, brain). Age-related mitochondrial decline. Barth syndrome and cardiolipin biology. Cardiac biology and cardiomyopathy research. This is one of the more extensively studied peptides in the catalog — the experimental data is substantial.

Product Specifications

  • Molecular weight: 639.8 Da
  • CAS: 736992-21-5
  • Purity: ≥98% (class-level specification)
  • Form: Lyophilized powder
  • SKU: CP-SS31

Selected lots are independently tested by Janoshik Analytical; search by batch or report code at certapeptides.com/verify. Search by code →

For research purposes only. Not for human consumption.

Size

10mg, 50mg

Consult the published report for lot-specific measured results.

SS-31 10mg

SS-31 10mg · Result: 99.841% · Measured content: 11.17 mg (111.7% of label) · Report Code: BFI6XX5CYX13 · Test Date: 2026-08-06 · Lab: Janoshik Analytical

View independent report #212156 ↗

SS-31 50mg

SS-31 50mg · Result: 99.634% · Measured content: 53.35 mg (106.7% of label) · Report Code: DMBTMNWVBJ86 · Test Date: 2026-06-19 · Lab: Janoshik Analytical

View independent report #172219 ↗

Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.

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Researcher Confidence

Why researchers choose CertaPeptides

Who actually tests this?

Selected lots are independently verified by Janoshik Analytical (Czech Republic) and published on the Janoshik public portal. Other lots ship with the supplier's batch specification. See /coa for the published wall.

View COAs →

What if I get the wrong batch?

Every vial label carries a code. Look it up on our Verify page: it shows what CertaPeptides publishes for that code and, for a withdrawn lot, that the lot was withdrawn and why. If yours is withdrawn, or if the code on your label finds nothing, email us that code.

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Where does it ship from?

Romania (EU). We are CERTALAB SRL, CUI 54169956, VAT-registered. Sameday for Romania, GLS for most EU destinations, TCE Worldwide for the remaining cross-border EU and non-EU markets (UK, Switzerland). Delivery 1–15 business days depending on destination — exact window shown at checkout.

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What if there's a problem?

You have a 14-day withdrawal right under OUG 34/2014 (Romanian/EU consumer law), with escalation to ANPC and alternative dispute resolution (SAL) available. Contact us at support@chinapeptideshop.com.

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Product Information

This product is intended for scientific research and development purposes only. It is a chemical substance that shall not be used as a drug, medicine, active substance, or ingredient in any product intended for human or animal consumption. Researchers must handle this compound in accordance with their institutional biosafety guidelines. Use only in properly equipped laboratory settings with appropriate personal protective equipment.

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