Adipotide
♢ Research use only Specifikacija klase; odabrane serije testira Janoshik
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Full shipping informationIstraživačka kvaliteta Adipotide. Specifikacija na razini klase ≥98%. Liofilizirani prah u zatvorenoj staklenoj bočici. Samo u istraživačke svrhe. Nije za ljudsku potrošnju.
O proizvodu Adipotide
Samo u istraživačke svrhe. Not for human or veterinary use.
Pregled
Adipotide (also written as FTPP, or by its sequence CKGGRAKDC-GG-D(KLAKLAK)2) is a proapoptotic peptidomimetic built for vascular targeting of white adipose tissue. Two functional halves are joined in a single molecule: a homing peptide, CKGGRAKDC, that binds prohibitin displayed on the endothelium of blood vessels feeding white fat, and a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes once it is internalised. The homing sequence was originally isolated through in vivo phage-display screening for peptides that localise to white adipose tissue vasculature, which is what gives the conjugate its tissue selectivity in research models.
The molecule was characterised by researchers at the University of Texas MD Anderson Cancer Center. It is frequently discussed as a conceptual parallel to antibody-drug conjugates: the cytotoxic payload is only delivered where the targeting element has bound, so activity is concentrated at the intended vascular bed rather than distributed systemically. CertaPeptides is a reseller and supplies Adipotide as a research reagent; we do not manufacture, formulate, or select the salt form of this compound.
Research Areas
Published literature has investigated Adipotide primarily as a tool for studying adipose-tissue vascular biology and the metabolic consequences of ablating fat-feeding vasculature. In the foundational mouse work, targeted ablation of adipose vasculature was used to study adipose-tissue remodelling and established prohibitin on adipose endothelium as an addressable target (Kolonin et al., 2004). A later non-human primate study examined tissue selectivity, metabolic parameters and renal markers (Barnhart et al., 2011). These two datasets remain the most cited reference points for researchers modelling vascular-targeting approaches to adipose tissue. Typical research questions include how selective prohibitin targeting is across different vascular beds, how model organisms respond to adipose vascular ablation, and how the conjugate format governs where apoptosis is triggered.
Specifications
| Compound | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Čistoća | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or PBS |
| Čuvanje | −20°C lyophilized; 2–8°C after reconstitution, use within 14 days |
Quality & Verification
The class-level specification on record is ≥98%. No independent report is on record for this product yet; independent reports on selected lots are searchable by batch or report code at certapeptides.com/verify. We make no in-house testing claim and do not test every batch. EU-based handling under CERTALAB S.R.L.
Često postavljana pitanja
What is adipotide used for in research?
In the published literature, adipotide is used as a research tool to study vascular targeting of white adipose tissue. It combines a peptide that homes to prohibitin on adipose-feeding blood vessels with a proapoptotic domain, letting researchers investigate what happens in model systems when that specific vasculature is ablated. It is supplied for laboratory research only and is not for human or veterinary use.
How does adipotide target fat tissue specifically?
The CKGGRAKDC portion of the molecule was identified through in vivo phage-display screening for peptides that home to white adipose tissue vasculature. Its target, prohibitin, is displayed on the endothelium of fat-feeding vessels. Once the homing peptide binds, the D(KLAKLAK)2 domain is internalised and disrupts mitochondrial membranes, so activity is concentrated at the targeted vascular bed rather than distributed broadly.
What did the primate study report?
Barnhart and colleagues (2011, Science Translational Medicine) studied adipotide in rhesus monkeys, reporting on tissue selectivity, metabolic parameters and renal markers in the model animals. This primate dataset is the most advanced preclinical reference point cited for the compound.
What is a proapoptotic peptide-drug conjugate?
It is a molecule that pairs a targeting peptide with a cell-death-inducing payload, conceptually similar to an antibody-drug conjugate. In adipotide, the targeting peptide delivers the D(KLAKLAK)2 domain to adipose endothelial cells; the payload only acts where the targeting element has bound, which is the source of the conjugate’s selectivity in research models.
How should adipotide be stored?
Store the lyophilized powder at −20°C, protected from light. After reconstitution with sterile water or PBS, keep refrigerated at 2–8°C and use within roughly 14 days. Handle in line with standard peptide-handling and institutional biosafety guidelines.
Samo u istraživačke svrhe. Nije za ljudsku potrošnju.
| Spoj | Adipotide / CKGGRAKDC-GG-D(KLAKLAK)2 |
|---|---|
| Čistoća | ≥98% (specifikacija na razini klase) |
| Oblik | Liofilizirani prah |
| Rekonstitucija | Sterilna voda ili PBS |
| Čuvanje | −20°C liofiliziran; 2–8°C nakon rekonstitucije, upotrijebiti unutar 14 dana |
No independent report is currently published for this product. A class-level specification is not an independent lot test.
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
Peptide Reconstitution Calculator →Povezano istraživačko štivo
Objektivne usporedbe i istraživački vodiči o ovom spoju. Referentni materijal isključivo u istraživačke svrhe.
Povjerenje istraživača
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Pogledaj COA →Odakle se otprema?
Rumunjska (EU). Mi smo CERTALAB SRL, CUI 54169956, registrirani za PDV. Sameday za Rumunjsku, GLS za većinu odredišta u EU-u, TCE Worldwide za ostala prekogranična tržišta EU-a i izvan EU-a (Ujedinjeno Kraljevstvo, Švicarska). Dostava 1–15 radnih dana ovisno o odredištu — točan rok prikazan je na blagajni.
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Pravila o povratu →Informacije o proizvodu
Ovaj je proizvod namijenjen isključivo za znanstvena istraživanja i razvoj. Riječ je o kemijskoj tvari koja se ne smije upotrebljavati kao lijek, medicinski pripravak, djelatna tvar ni sastojak u bilo kojem proizvodu namijenjenom ljudskoj ili životinjskoj potrošnji. Istraživači moraju s ovim spojem rukovati u skladu sa smjernicama biološke sigurnosti svoje ustanove. Upotrebljavajte ga isključivo u primjereno opremljenim laboratorijskim uvjetima uz odgovarajuću osobnu zaštitnu opremu.
Peptidi u liofiliziranom (sušenom smrzavanjem) obliku otpremaju se u zatvorenim staklenim bočicama standardnim metodama dostave i ne zahtijevaju hlađenje tijekom transporta. Liofilizirani peptidi vrlo su stabilni na sobnoj temperaturi tijekom trajanja standardne dostave (uobičajeni rokovi transporta prikazani su na blagajni). Nakon primitka proizvod odmah prenesite na rashlađeno čuvanje (2–8°C).
Često postavljana pitanja
Istraživački peptidi isporučuju se u liofiliziranom (sušenom smrzavanjem) obliku. Količina materijala obično iznosi tek nekoliko miligrama — pojavljuje se kao vrlo tanak film ili mala peleta na dnu bočice, često gotovo nevidljiva. To je posve normalno.
Za razliku od nekih dobavljača koji dodaju punila u rasutom stanju (poput manitola), CertaPeptides isporučuje čisti peptid bez nepotrebnih dodataka.
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