LL-37 5mg
LL-37 5mg · Result: 99.379% · Measured content: 4.74 mg (94.8% of label) · Report Code: D84HFXBSQWJ7 · Test Date: 2026-09-18 · Lab: Janoshik Analytical
View independent report #233646 ↗LL-37 5mg
♢ Research use only Specifikacija na ravni razreda; izbrane serije testira Janoshik
✓ Janoshik Verified 99.379%LL-37 5mg · Report #233646 ↗€76.99
Free standard EU shipping on orders over €200
If a product doesn't match the specification on its published COA, contact us with your batch number: we investigate against the lot's report and replace any product that fails it, at no cost to you.
Contact us within 48 hours of delivery with photos of the outer box, inner packing, and any affected vials with labels legible. Confirmed transit damage is replaced at no cost to you.
Returns policy →Shipping estimate for EU
3–7 days most of the EU · 10–14 Nordics/Baltics. Dispatched within 1–2 business days. Check destination rates at checkout.
Full shipping informationLL-37 je 37-aminokislinski peptid iz družine katelicidinov. Je edini človeški katelicidin in je bil široko preučevan zaradi vloge pri signalizaciji prirojene imunosti in raziskavah peptidov obrambe gostitelja. Človeški katelicidinski peptid obrambe gostitelja Študije signalizacije prirojene imunosti in interakcij z membranami Raziskave motenja biofilma in mikrobiologije Samo za raziskovalne namene. Ni za prehrano ljudi.
O izdelku LL-37 5mg
LL-37 is the only human cathelicidin — a class of host defense peptides that bridge innate immunity and antimicrobial defense. It is derived from the C-terminus of the hCAP-18 protein (human cathelicidin antimicrobial protein 18), processed by serine proteases into the active 37-amino acid LL-37 form. The name reflects its structure: it begins with two leucine residues (LL) and is 37 amino acids long. Despite being the sole human cathelicidin, it is expressed in neutrophils, epithelial cells of the skin, gut, lung, and urogenital tract — providing frontline defense at multiple barrier sites.
LL-37’s antimicrobial mechanism involves disruption of bacterial membranes. Its amphipathic alpha-helical structure allows it to insert into and permeabilize bacterial lipid bilayers, killing a broad spectrum of gram-positive and gram-negative bacteria, fungi, and enveloped viruses. It also binds and neutralizes bacterial LPS (endotoxin), a mechanism studied in models of endotoxin signalling. Beyond direct killing, LL-37 has extensive immunomodulatory functions — it activates epithelial cells, macrophages, and dendritic cells, modulates TLR signaling, and is studied for fibroblast and angiogenesis responses in tissue-repair model systems.
Research interest spans antimicrobial-peptide biology, tissue-repair model systems, skin-barrier-model and lung host-defense research, anti-biofilm strategies, and oncology research (LL-37 has context-dependent pro- and anti-tumor effects in different cancer models).
Specifications
| Parameter | Value |
|---|---|
| Compound | LL-37 (human cathelicidin antimicrobial peptide, 37 aa) |
| Amount per Vial | 5mg |
| Čistost | ≥98% (class-level specification); selected lots independently tested by Janoshik, searchable by batch or report code at certapeptides.com/verify |
| Format | Lyophilized powder |
| Reconstitution | Sterile water; avoid high salt concentrations |
| Shranjevanje | -20°C; 2-8°C after reconstitution |
Shranjevanje
Store at -20°C. LL-37 can aggregate in high ionic strength solutions — reconstitute in low-salt buffer or sterile water and then add buffer. Refrigerate at 2-8°C after reconstitution and use within 14 days. Avoid repeated freeze-thaw.
How does LL-37 kill bacteria without killing host cells?
LL-37 kills bacteria by disrupting their membranes through its amphipathic alpha-helical structure — one face of the helix is hydrophobic, the other cationic. Bacterial membranes are negatively charged due to high phosphatidylglycerol and cardiolipin content, attracting the cationic LL-37. Once bound, the peptide inserts into and permeabilizes the bacterial membrane. Mammalian cell membranes are primarily zwitterionic (net neutral) and are less susceptible to this mechanism, though selectivity is concentration-dependent. High LL-37 concentrations can lyse mammalian cells. Research protocols must account for this concentration-dependent selectivity.
Why is LL-37 the only human cathelicidin?
While mice and many other mammals have multiple cathelicidin genes, humans have only one — the CAMP gene encoding the hCAP-18/LL-37 precursor. The reasons for this reduction to a single cathelicidin in human evolution are not fully understood, but it may relate to immune system specialization in humans toward other defense mechanisms. Despite being alone in its class, LL-37 is expressed at many epithelial surfaces and in immune cells, and its immunomodulatory functions extend well beyond direct antimicrobial killing — suggesting it has evolved to serve multiple host defense roles that might be distributed across multiple cathelicidins in other species.
What is LL-37’s role in tissue-repair model research?
LL-37 is studied for tissue-repair responses in model systems through several mechanisms. In cited models it is associated with keratinocyte migration and proliferation, angiogenesis signalling through VEGF and FGF receptor pathways, and modulation of the inflammatory phase of tissue-repair models, alongside anti-biofilm activity studied in antimicrobial-model systems. These properties have made LL-37 of interest in barrier-model and anti-biofilm research. LL-37-functionalised dressings and scaffolds have also been investigated in tissue-repair model systems.
LL-37 is supplied for research purposes only. Not for human use. Handle in compliance with institutional biosafety guidelines.
| Parameter | Vrednost |
|---|---|
| Spojina | LL-37 (človeški katelicidinski protimikrobni peptid, 37 aa) |
| Količina na vialo | 5mg |
| Čistost | ≥98% (specifikacija na ravni razreda); izbrane serije so neodvisno testirane pri Janoshik, mogoče jih je poiskati po kodi serije ali poročila na certapeptides.com/verify |
| Oblika | Liofiliziran prašek |
| Rekonstitucija | Sterilna voda; izogniti se visokim koncentracijam soli |
| Shranjevanje | -20°C; 2-8°C po rekonstituciji |
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
Peptide Reconstitution Calculator →Kaj kažejo raziskave
Izbrane recenzirane študije iz objavljene literature. Vsaka opisuje laboratorijske ali predklinične ugotovitve in je pripisana navedeni študiji, ne temu izdelku. Samo za raziskovalne namene — ne medicinski nasvet.
[1]
Immunomodulation
In cultured macrophages, LL-37 was shown to inhibit LPS/ATP-induced pyroptosis through a dual mechanism in in-vitro research.
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism. PLoS One (2014). PMID: 24454930Navedbe so podane kot raziskovalna referenca. CertaPeptides (CERTALAB S.R.L.) je preprodajalec, ne proizvajalec, in ne navaja nobenih medicinskih, terapevtskih trditev ali trditev o učinkovitosti. Izdelki so samo za raziskovalne namene in niso za uživanje pri ljudeh ali živalih.
Zaupanje raziskovalcev
Zakaj raziskovalci izberejo CertaPeptides
Kdo to dejansko testira?
Izbrane lote neodvisno preverja Janoshik Analytical (Češka) in jih objavi na javnem portalu Janoshik. Drugi loti se odpremijo s specifikacijo dobaviteljeve serije. Objavljeno steno si oglejte na /coa.
Ogled COA →Kaj pa, če dobim napačno serijo?
Vsaka etiketa na viali nosi kodo. Poiščite jo na naši strani za preverjanje: ta prikaže, kar CertaPeptides objavlja za to kodo, pri umaknjeni seriji pa tudi, da je bila umaknjena, in zakaj. Če je vaša serija umaknjena ali če iskanje kode z vaše etikete ne najde ničesar, nam to kodo pošljite po e-pošti.
Ogled COA →Od kod se odpremlja?
Iz Romunije (EU). Smo CERTALAB SRL, CUI 54169956, registrirani za DDV. Sameday za Romunijo, GLS za večino destinacij v EU, TCE Worldwide za preostale čezmejne trge v EU in zunaj EU (Združeno kraljestvo, Švica). Dostava 1–15 delovnih dni glede na destinacijo — natančno okno je prikazano ob zaključku naročila.
Podrobnosti o dostavi →Kaj pa, če pride do težave?
Imate 14-dnevno pravico do odstopa po OUG 34/2014 (romunsko/EU potrošniško pravo), z možnostjo eskalacije na ANPC in izvensodnega reševanja sporov (SAL). Kontaktirajte nas na support@chinapeptideshop.com.
Politika vračil →Podatki o izdelku
Ta izdelek je namenjen izključno znanstvenoraziskovalnim in razvojnim namenom. Gre za kemično snov, ki se ne sme uporabljati kot zdravilo, učinkovina ali sestavina v katerem koli izdelku, namenjenem prehrani ljudi ali živali. Raziskovalci morajo s to spojino ravnati skladno s svojimi institucionalnimi smernicami za biološko varnost. Uporabljajte jo le v ustrezno opremljenih laboratorijskih okoljih z ustrezno osebno zaščitno opremo.
Peptidi v liofilizirani (zamrznjeno sušeni) obliki se pošiljajo v zaprtih steklenih vialah s standardnimi načini dostave in med prevozom ne potrebujejo hlajenja. Liofilizirani peptidi so zelo stabilni pri sobnih temperaturah ves čas standardnega pošiljanja (običajni časi prevoza so prikazani pri zaključku nakupa). Po prejemu izdelek nemudoma prenesite v hlajeno shranjevanje (2–8 °C).
Pogosta vprašanja
Raziskovalni peptidi se dobavljajo v liofilizirani (zamrznjeno sušeni) obliki. Količina materiala je običajno le nekaj miligramov — videti je kot zelo tanek film ali majhna kroglica na dnu viale, pogosto skoraj nevidna. To je popolnoma normalno.
Za razliko od nekaterih dobaviteljev, ki dodajajo polnila (kot je manitol), CertaPeptides zagotavlja čist peptid brez nepotrebnih dodatkov.
Raziskovalna knjižnica
Sorodni raziskovalni članki
Frequently researched together
LL-37 5mg
MT-2 (Melanotan 2 Acetate)
GHK-Cu
BPC-157Combined Price €161.96
View All Products