LL-37 5mg
LL-37 5mg · Result: 99.379% · Measured content: 4.74 mg (94.8% of label) · Report Code: D84HFXBSQWJ7 · Test Date: 2026-09-18 · Lab: Janoshik Analytical
View independent report #233646 ↗LL-37 5mg
♢ Research use only Klassespecifikation; udvalgte partier Janoshik-testet
✓ Janoshik Verified 99.379%LL-37 5mg · Report #233646 ↗€76.99
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Full shipping informationLL-37 er et peptid med 37 aminosyrer, der tilhører cathelicidin-familien. Det er det eneste humane cathelicidin og er bredt undersøgt for sin rolle i medfødt immunsignalering og forskning i værtsforsvarspeptider. Humant cathelicidin-værtsforsvarspeptid Studier af medfødt immunsignalering og membraninteraktion Biofilm-forstyrrelse og mikrobiologisk forskning Kun til forskningsformål. Ikke til human konsum.
Om LL-37 5mg
LL-37 is the only human cathelicidin — a class of host defense peptides that bridge innate immunity and antimicrobial defense. It is derived from the C-terminus of the hCAP-18 protein (human cathelicidin antimicrobial protein 18), processed by serine proteases into the active 37-amino acid LL-37 form. The name reflects its structure: it begins with two leucine residues (LL) and is 37 amino acids long. Despite being the sole human cathelicidin, it is expressed in neutrophils, epithelial cells of the skin, gut, lung, and urogenital tract — providing frontline defense at multiple barrier sites.
LL-37’s antimicrobial mechanism involves disruption of bacterial membranes. Its amphipathic alpha-helical structure allows it to insert into and permeabilize bacterial lipid bilayers, killing a broad spectrum of gram-positive and gram-negative bacteria, fungi, and enveloped viruses. It also binds and neutralizes bacterial LPS (endotoxin), a mechanism studied in models of endotoxin signalling. Beyond direct killing, LL-37 has extensive immunomodulatory functions — it activates epithelial cells, macrophages, and dendritic cells, modulates TLR signaling, and is studied for fibroblast and angiogenesis responses in tissue-repair model systems.
Research interest spans antimicrobial-peptide biology, tissue-repair model systems, skin-barrier-model and lung host-defense research, anti-biofilm strategies, and oncology research (LL-37 has context-dependent pro- and anti-tumor effects in different cancer models).
Specifications
| Parameter | Value |
|---|---|
| Compound | LL-37 (human cathelicidin antimicrobial peptide, 37 aa) |
| Amount per Vial | 5mg |
| Renhed | ≥98% (class-level specification); selected lots independently tested by Janoshik, searchable by batch or report code at certapeptides.com/verify |
| Format | Lyophilized powder |
| Reconstitution | Sterile water; avoid high salt concentrations |
| Opbevaring | -20°C; 2-8°C after reconstitution |
Opbevaring
Store at -20°C. LL-37 can aggregate in high ionic strength solutions — reconstitute in low-salt buffer or sterile water and then add buffer. Refrigerate at 2-8°C after reconstitution and use within 14 days. Avoid repeated freeze-thaw.
How does LL-37 kill bacteria without killing host cells?
LL-37 kills bacteria by disrupting their membranes through its amphipathic alpha-helical structure — one face of the helix is hydrophobic, the other cationic. Bacterial membranes are negatively charged due to high phosphatidylglycerol and cardiolipin content, attracting the cationic LL-37. Once bound, the peptide inserts into and permeabilizes the bacterial membrane. Mammalian cell membranes are primarily zwitterionic (net neutral) and are less susceptible to this mechanism, though selectivity is concentration-dependent. High LL-37 concentrations can lyse mammalian cells. Research protocols must account for this concentration-dependent selectivity.
Why is LL-37 the only human cathelicidin?
While mice and many other mammals have multiple cathelicidin genes, humans have only one — the CAMP gene encoding the hCAP-18/LL-37 precursor. The reasons for this reduction to a single cathelicidin in human evolution are not fully understood, but it may relate to immune system specialization in humans toward other defense mechanisms. Despite being alone in its class, LL-37 is expressed at many epithelial surfaces and in immune cells, and its immunomodulatory functions extend well beyond direct antimicrobial killing — suggesting it has evolved to serve multiple host defense roles that might be distributed across multiple cathelicidins in other species.
What is LL-37’s role in tissue-repair model research?
LL-37 is studied for tissue-repair responses in model systems through several mechanisms. In cited models it is associated with keratinocyte migration and proliferation, angiogenesis signalling through VEGF and FGF receptor pathways, and modulation of the inflammatory phase of tissue-repair models, alongside anti-biofilm activity studied in antimicrobial-model systems. These properties have made LL-37 of interest in barrier-model and anti-biofilm research. LL-37-functionalised dressings and scaffolds have also been investigated in tissue-repair model systems.
LL-37 is supplied for research purposes only. Not for human use. Handle in compliance with institutional biosafety guidelines.
| Parameter | Værdi |
|---|---|
| Forbindelse | LL-37 (humant cathelicidin-antimikrobielt peptid, 37 aa) |
| Mængde pr. hætteglas | 5mg |
| Renhed | ≥98% (specifikation på klasseniveau); udvalgte partier er uafhængigt testet af Janoshik og kan søges frem via batch- eller rapportkode på certapeptides.com/verify |
| Format | Lyofiliseret pulver |
| Rekonstitution | Sterilt vand; undgå høje saltkoncentrationer |
| Opbevaring | -20°C; 2-8°C efter rekonstitution |
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
Peptide Reconstitution Calculator →Hvad forskningen viser
Udvalgte fagfællebedømte studier fra den offentliggjorte litteratur. Hvert beskriver laboratorie- eller prækliniske resultater og er tilskrevet det citerede studie, ikke dette produkt. Kun til forskningsformål — ikke medicinsk vejledning.
[1]
Immunomodulation
In cultured macrophages, LL-37 was shown to inhibit LPS/ATP-induced pyroptosis through a dual mechanism in in-vitro research.
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism. PLoS One (2014). PMID: 24454930Citater er angivet til forskningsreference. CertaPeptides (CERTALAB S.R.L.) er en forhandler, ikke en producent, og fremsætter ingen medicinske, terapeutiske eller virkningsmæssige påstande. Produkter er udelukkende til forskningsformål og er ikke til konsum for mennesker eller dyr.
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Returpolitik →Produktinformation
Dette produkt er udelukkende beregnet til videnskabelig forskning og udvikling. Det er et kemisk stof, der ikke må anvendes som lægemiddel, medicin, aktivt stof eller ingrediens i noget produkt beregnet til konsum hos mennesker eller dyr. Forskere skal håndtere denne forbindelse i overensstemmelse med deres institutions biosikkerhedsretningslinjer. Må kun anvendes i korrekt udstyrede laboratoriemiljøer med passende personlige værnemidler.
Peptider i lyofiliseret (frysetørret) form sendes i forseglede glasvials med standardleveringsmetoder og kræver ikke køling under transport. Lyofiliserede peptider er meget stabile ved omgivelsestemperaturer i standardforsendelsens varighed (typiske transittider vises ved checkout). Efter modtagelse skal produktet hurtigt overføres til køleopbevaring (2–8°C).
Ofte stillede spørgsmål
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Forskningsbibliotek
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