MT-2 (Melanotan 2 Acetate)
MT-2 (Melanotan 2 Acetate) · Result: 99.455% · Measured content: 10.45 mg (104.5% of label) · Report Code: PALC8VXE3661 · Test Date: 2026-09-18 · Lab: Janoshik Analytical
View independent report #233663 ↗Melanocortin and Pigment Research Peptides SKU: CP-MT2
MT-2 (Melanotan 2 Acetate)
♢ Research use only Klassespecifikation; udvalgte partier Janoshik-testet
✓ Janoshik Verified 99.455%MT-2 (Melanotan 2 Acetate) · Report #233663 ↗Free standard EU shipping on orders over €200
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Full shipping informationMelanotan II (MT-2) er en syntetisk cyklisk heptapeptidanalog af alpha-MSH med potent melanocortin-receptoragonistaktivitet. Binder MC1R, MC3R, MC4R, MC5R. Studeres i forskningsmodeller for melanogenese og energihomeostase. Leveres som lyofiliseret pulver; specifikation på klasseniveau ≥98%; udvalgte partier er uafhængigt testet. Kun til forskningsformål. Ikke til human anvendelse.
Om MT-2 (Melanotan 2 Acetate)
Melanotan II (MT-2) is a synthetic cyclic analogue of alpha-MSH (alpha-melanocyte-stimulating hormone), a peptide derived from POMC (proopiomelanocortin). It is a potent, non-selective agonist at melanocortin receptors (MC1R through MC5R), with particularly strong activity at MC1R and MC4R. This broad agonism is studied in research models in connection with both its well-characterised activity on skin pigmentation (via MC1R) and its research history around sexual-arousal pharmacology and appetite modulation (via MC4R).
The pharmacology is worth understanding in some detail. MC1R is expressed on melanocytes and regulates melanin production — in research models MT-2 is studied for activation of eumelanin synthesis, associated with darker skin pigmentation without UV exposure. MC4R is expressed in the hypothalamus and plays roles in melanocortin signalling and sexual function — in research models its activation is studied for satiety signalling and, notably, pro-erectile effects in male rodent models. MC3R has roles in energy homeostasis. MT-2 activates all of these nonselectively, which produces the compound’s range of effects in research models and also complicates research interpretation where receptor-specific effects need to be isolated.
MT-2 was developed at the University of Arizona from research aimed at characterizing a compound that would drive melanin synthesis in model systems and, in turn, was studied in the context of UV-related skin biology. The broader melanocortin agonism effects became apparent during development. It has been investigated in preclinical research on sexual-arousal pharmacology, and a related derivative (bremelanotide/PT-141) shares the same MC4R-mediated mechanism.
Specifications
| Parameter | Value |
|---|---|
| Compound | Melanotan II acetate (cyclic alpha-MSH analogue) |
| Renhed | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Bacteriostatic water |
| Opbevaring | -20°C; 2-8°C after reconstitution, protect from light |
Opbevaring
Store at -20°C and protect from light. MT-2 is light-sensitive. Refrigerate after reconstitution at 2-8°C. Lyophilized powder is stable for 24+ months under proper storage.
What melanocortin receptors does MT-2 activate?
MT-2 is a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R, and MC5R. MC1R mediates skin and hair pigmentation (studied in research models for activation of eumelanin synthesis in melanocytes). MC3R and MC4R are expressed in the hypothalamus and have roles in energy homeostasis, appetite, and sexual function. In research models, MC4R activation is studied for MT-2’s pro-erectile effects in rodent models and its satiety effects. MC5R has roles in exocrine gland function. MT-2’s lack of receptor selectivity is a key consideration for research design when receptor-specific effects need to be distinguished.
How does MT-2 relate to PT-141 (bremelanotide)?
PT-141 (bremelanotide) is a metabolite of MT-2 that differs only at the C-terminus (a free acid instead of an amide); both peptides are cyclic. In research, it is the compound associated with the MC4R-mediated sexual-arousal pharmacology rather than the tanning or other melanocortin effects. MT-2 is the research precursor that established the MC4R-mediated arousal pharmacology that PT-141 was developed from.
What was the original research goal for MT-2?
MT-2 was developed at the University of Arizona in the 1980s-90s with the goal of characterizing a compound that would produce melanin synthesis without UV exposure in model systems, studied in the context of UV-related skin biology. The pro-pigmentation activity via MC1R was the primary target. The broader melanocortin receptor agonism — including the MC4R-mediated effects on sexual arousal and appetite in animal models — was discovered during development and shifted the research direction significantly.
Melanotan II is supplied for research purposes only. Not for human use. Handle in compliance with institutional biosafety guidelines.
| Parameter | Værdi |
|---|---|
| Forbindelse | Melanotan II-acetat (cyklisk alpha-MSH-analog) |
| Renhed | ≥98% (specifikation på klasseniveau) |
| Format | Lyofiliseret pulver |
| Rekonstitution | Bakteriostatisk vand |
| Opbevaring | -20°C; 2-8°C efter rekonstitution, beskyttes mod lys |
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
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Dette produkt er udelukkende beregnet til videnskabelig forskning og udvikling. Det er et kemisk stof, der ikke må anvendes som lægemiddel, medicin, aktivt stof eller ingrediens i noget produkt beregnet til konsum hos mennesker eller dyr. Forskere skal håndtere denne forbindelse i overensstemmelse med deres institutions biosikkerhedsretningslinjer. Må kun anvendes i korrekt udstyrede laboratoriemiljøer med passende personlige værnemidler.
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