MT-2 (Melanotan 2 Acetate)
MT-2 (Melanotan 2 Acetate) · Result: 99.455% · Measured content: 10.45 mg (104.5% of label) · Report Code: PALC8VXE3661 · Test Date: 2026-09-18 · Lab: Janoshik Analytical
View independent report #233663 ↗Melanocortin and Pigment Research Peptides SKU: CP-MT2
MT-2 (Melanotan 2 Acetate)
♢ Research use only Especificación a nivel de clase; lotes seleccionados probados por Janoshik
✓ Janoshik Verified 99.455%MT-2 (Melanotan 2 Acetate) · Report #233663 ↗Free standard EU shipping on orders over €200
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Full shipping informationEl Melanotan II (MT-2) es un heptapéptido cíclico sintético análogo de la alfa-MSH con potente actividad agonista de los receptores de melanocortina. Se une al MC1R, el MC3R, el MC4R y el MC5R. Estudiado en modelos de investigación por la melanogénesis y la homeostasis energética. Suministrado como polvo liofilizado; especificación a nivel de clase ≥98%; lotes seleccionados probados de forma independiente. Solo para fines de investigación. No apto para el consumo humano.
Descripción
Melanotan II (MT-2) is a synthetic cyclic analogue of alpha-MSH (alpha-melanocyte-stimulating hormone), a peptide derived from POMC (proopiomelanocortin). It is a potent, non-selective agonist at melanocortin receptors (MC1R through MC5R), with particularly strong activity at MC1R and MC4R. This broad agonism is studied in research models in connection with both its well-characterised activity on skin pigmentation (via MC1R) and its research history around sexual-arousal pharmacology and appetite modulation (via MC4R).
The pharmacology is worth understanding in some detail. MC1R is expressed on melanocytes and regulates melanin production — in research models MT-2 is studied for activation of eumelanin synthesis, associated with darker skin pigmentation without UV exposure. MC4R is expressed in the hypothalamus and plays roles in melanocortin signalling and sexual function — in research models its activation is studied for satiety signalling and, notably, pro-erectile effects in male rodent models. MC3R has roles in energy homeostasis. MT-2 activates all of these nonselectively, which produces the compound’s range of effects in research models and also complicates research interpretation where receptor-specific effects need to be isolated.
MT-2 was developed at the University of Arizona from research aimed at characterizing a compound that would drive melanin synthesis in model systems and, in turn, was studied in the context of UV-related skin biology. The broader melanocortin agonism effects became apparent during development. It has been investigated in preclinical research on sexual-arousal pharmacology, and a related derivative (bremelanotide/PT-141) shares the same MC4R-mediated mechanism.
Specifications
| Parameter | Value |
|---|---|
| Compound | Melanotan II acetate (cyclic alpha-MSH analogue) |
| Pureza | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Bacteriostatic water |
| Almacenamiento | -20°C; 2-8°C after reconstitution, protect from light |
Almacenamiento
Store at -20°C and protect from light. MT-2 is light-sensitive. Refrigerate after reconstitution at 2-8°C. Lyophilized powder is stable for 24+ months under proper storage.
What melanocortin receptors does MT-2 activate?
MT-2 is a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R, and MC5R. MC1R mediates skin and hair pigmentation (studied in research models for activation of eumelanin synthesis in melanocytes). MC3R and MC4R are expressed in the hypothalamus and have roles in energy homeostasis, appetite, and sexual function. In research models, MC4R activation is studied for MT-2’s pro-erectile effects in rodent models and its satiety effects. MC5R has roles in exocrine gland function. MT-2’s lack of receptor selectivity is a key consideration for research design when receptor-specific effects need to be distinguished.
How does MT-2 relate to PT-141 (bremelanotide)?
PT-141 (bremelanotide) is a metabolite of MT-2 that differs only at the C-terminus (a free acid instead of an amide); both peptides are cyclic. In research, it is the compound associated with the MC4R-mediated sexual-arousal pharmacology rather than the tanning or other melanocortin effects. MT-2 is the research precursor that established the MC4R-mediated arousal pharmacology that PT-141 was developed from.
What was the original research goal for MT-2?
MT-2 was developed at the University of Arizona in the 1980s-90s with the goal of characterizing a compound that would produce melanin synthesis without UV exposure in model systems, studied in the context of UV-related skin biology. The pro-pigmentation activity via MC1R was the primary target. The broader melanocortin receptor agonism — including the MC4R-mediated effects on sexual arousal and appetite in animal models — was discovered during development and shifted the research direction significantly.
Melanotan II is supplied for research purposes only. Not for human use. Handle in compliance with institutional biosafety guidelines.
| Parámetro | Valor |
|---|---|
| Compuesto | Melanotan II acetato (análogo cíclico de la alfa-MSH) |
| Pureza | ≥98% (especificación a nivel de clase) |
| Formato | Polvo liofilizado |
| Reconstitución | Agua bacteriostática |
| Almacenamiento | -20°C; 2-8°C tras la reconstitución, proteger de la luz |
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
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Política de devoluciones →Información del producto
Este producto está destinado únicamente a fines de investigación y desarrollo científicos. Es una sustancia química que no debe utilizarse como fármaco, medicamento, principio activo ni ingrediente en ningún producto destinado al consumo humano o animal. Los investigadores deben manipular este compuesto de acuerdo con las directrices de bioseguridad de su institución. Utilícese únicamente en entornos de laboratorio debidamente equipados y con el equipo de protección individual adecuado.
Los péptidos en forma liofilizada (secada por congelación) se envían en viales de vidrio sellados mediante métodos de envío estándar y no requieren refrigeración durante el tránsito. Los péptidos liofilizados son muy estables a temperatura ambiente durante el tiempo del envío estándar (los plazos de tránsito habituales se indican al finalizar la compra). Una vez recibidos, transfiera el producto a almacenamiento refrigerado (2–8°C) sin demora.
Preguntas frecuentes
Los péptidos de investigación se suministran en forma liofilizada (secada por congelación). La cantidad de material suele ser de tan solo unos pocos miligramos, presentándose como una película muy fina o un pequeño sedimento en el fondo del vial, a menudo casi invisible. Esto es completamente normal.
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