SNAP-8 10mg
SNAP-8 10mg · Result: 99.931% · Measured content: 10.78 mg (107.8% of label) · Report Code: KT9FA5IJ9TYA · Test Date: 2026-09-18 · Lab: Janoshik Analytical
View independent report #233652 ↗Dermatological and Skin Research Compounds SKU: CP-NP810
SNAP-8 10mg
♢ Research use only Specifikacija na ravni razreda; izbrane serije testira Janoshik
✓ Janoshik Verified 99.931%SNAP-8 10mg · Report #233652 ↗€25.49
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Full shipping informationSNAP-8 (Acetyl Octapeptide-3) je sintetični oktapeptid, ki posnema N-terminalno domeno SNAP-25. Preučuje se za moduliranje aktivnosti živčno-mišičnega stika. Dobavlja se kot liofiliziran prašek; specifikacija na ravni razreda ≥98%; izbrane serije so neodvisno testirane. Samo za raziskovalne namene. Ni za prehrano ljudi.
O izdelku SNAP-8 10mg
SNAP-8 (Acetyl Glutamyl Heptapeptide-3) is a synthetic octapeptide that acts as a competitive antagonist of SNAP-25, one of the SNARE complex proteins involved in vesicle fusion at neuromuscular junctions. The mechanism mirrors what botulinum toxin does at a structural level — disrupting the SNARE machinery that triggers acetylcholine release — but achieves this through peptide competition rather than enzymatic cleavage. SNAP-25 is a 206-residue membrane-associated protein; SNAP-8 mimics a small segment of it to compete for the assembly of the fusion complex.
Research Applications
The primary research interest in SNAP-8 is mechanistic: it provides a way to study neuromuscular transmission and vesicle exocytosis without the safety complications of using the botulinum toxin itself. Because it acts through competitive inhibition rather than irreversible protease activity, its effects are concentration-dependent and reversible within the experimental timescale — which gives researchers more control over dose-response characterization.
Dermatological research has also used SNAP-8 as a model compound for studying topical peptide delivery and its effects on facial muscle contraction patterns. Whether peptide applied to skin surface can reach neuromuscular junctions in sufficient concentration to produce measurable physiological effects is genuinely debated. Some ex vivo skin models and some small experimental measurements have shown signals, others have not. The question of penetration depth relative to target depth remains unsettled. SNAP-8 is a useful tool compound for investigating this penetration question directly.
Specifications
| Parameter | Value |
|---|---|
| Active compound | SNAP-8 (Acetyl Glutamyl Heptapeptide-3) |
| Količina | 10mg lyophilized powder |
| Čistost | ≥98% (class-level specification) |
| Molecular weight | 1075.2 Da |
| Target protein | SNAP-25 (synaptosomal-associated protein 25) |
| Mechanism | SNARE complex competitive inhibition |
| Oblika | Lyophilized powder |
| Independent testing | Selected lots tested by Janoshik Analytical; searchable at certapeptides.com/verify |
Shranjevanje
Store at -20°C, away from light and moisture. Reconstitute in sterile water at the concentration needed for your assay. Reconstituted solution is stable at 4°C for up to 14 days. Not compatible with strong reducing agents, which can alter the acetyl group. For vesicle fusion assays, prepare fresh dilutions immediately before use.
How does SNAP-8 compare to botulinum toxin as a research tool?
Botulinum toxin cleaves SNARE proteins irreversibly through enzymatic activity, which makes dose-response experiments difficult once you are past the threshold. It also requires strict biohazard handling. SNAP-8 offers a reversible, concentration-dependent handle on the same pathway with far simpler logistics. The trade-off is potency — botulinum toxin is active at subnanomolar concentrations while SNAP-8 is effective in the micromolar range. For mechanistic studies of SNARE assembly kinetics, SNAP-8 is often the more tractable choice.
What in vitro models are appropriate for SNAP-8 research?
Liposome fusion assays using fluorescent lipid mixing are the standard for quantifying SNARE-mediated membrane fusion in a minimal reconstituted system. Neuronal cell cultures (PC12 cells or primary motor neurons) with catecholamine release readouts offer a more physiologically relevant model. Electrophysiological assays in cultured neuromuscular preparations allow direct measurement of miniature end-plate potential frequency changes. Each model has different artifacts to control for, so converging evidence from at least two systems strengthens mechanistic conclusions.
SNAP-8 is supplied for laboratory research. Not for human consumption. For research purposes only.
| Parameter | Vrednost |
|---|---|
| Aktivna spojina | SNAP-8 (Acetyl Glutamyl Heptapeptide-3) |
| Količina | 10mg liofiliziran prašek |
| Čistost | ≥98% (specifikacija na ravni razreda) |
| Molekulska masa | 1075.2 Da |
| Tarčna beljakovina | SNAP-25 (synaptosomal-associated protein 25) |
| Mehanizem | Kompetitivna inhibicija kompleksa SNARE |
| Oblika | Liofiliziran prašek |
| Neodvisno testiranje | Izbrane serije testira Janoshik Analytical; iskalno na certapeptides.com/verify |
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
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Iz Romunije (EU). Smo CERTALAB SRL, CUI 54169956, registrirani za DDV. Sameday za Romunijo, GLS za večino destinacij v EU, TCE Worldwide za preostale čezmejne trge v EU in zunaj EU (Združeno kraljestvo, Švica). Dostava 1–15 delovnih dni glede na destinacijo — natančno okno je prikazano ob zaključku naročila.
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Politika vračil →Podatki o izdelku
Ta izdelek je namenjen izključno znanstvenoraziskovalnim in razvojnim namenom. Gre za kemično snov, ki se ne sme uporabljati kot zdravilo, učinkovina ali sestavina v katerem koli izdelku, namenjenem prehrani ljudi ali živali. Raziskovalci morajo s to spojino ravnati skladno s svojimi institucionalnimi smernicami za biološko varnost. Uporabljajte jo le v ustrezno opremljenih laboratorijskih okoljih z ustrezno osebno zaščitno opremo.
Peptidi v liofilizirani (zamrznjeno sušeni) obliki se pošiljajo v zaprtih steklenih vialah s standardnimi načini dostave in med prevozom ne potrebujejo hlajenja. Liofilizirani peptidi so zelo stabilni pri sobnih temperaturah ves čas standardnega pošiljanja (običajni časi prevoza so prikazani pri zaključku nakupa). Po prejemu izdelek nemudoma prenesite v hlajeno shranjevanje (2–8 °C).
Pogosta vprašanja
Raziskovalni peptidi se dobavljajo v liofilizirani (zamrznjeno sušeni) obliki. Količina materiala je običajno le nekaj miligramov — videti je kot zelo tanek film ali majhna kroglica na dnu viale, pogosto skoraj nevidna. To je popolnoma normalno.
Za razliko od nekaterih dobaviteljev, ki dodajajo polnila (kot je manitol), CertaPeptides zagotavlja čist peptid brez nepotrebnih dodatkov.
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