SNAP-8 10mg
SNAP-8 10mg · Result: 99.931% · Measured content: 10.78 mg (107.8% of label) · Report Code: KT9FA5IJ9TYA · Test Date: 2026-09-18 · Lab: Janoshik Analytical
View independent report #233652 ↗Dermatological and Skin Research Compounds SKU: CP-NP810
SNAP-8 10mg
♢ Research use only Klassespecifikation; udvalgte partier Janoshik-testet
✓ Janoshik Verified 99.931%SNAP-8 10mg · Report #233652 ↗€25.49
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Full shipping informationSNAP-8 (Acetyl Octapeptide-3) er et syntetisk oktapeptid, der efterligner det N-terminale domæne af SNAP-25. Undersøgt for modulering af aktivitet ved neuromuskulære endeplader. Leveres som lyofiliseret pulver; specifikation på klasseniveau ≥98%; udvalgte partier er uafhængigt testet. Kun til forskningsformål. Ikke beregnet til menneskelig indtagelse.
Om SNAP-8 10mg
SNAP-8 (Acetyl Glutamyl Heptapeptide-3) is a synthetic octapeptide that acts as a competitive antagonist of SNAP-25, one of the SNARE complex proteins involved in vesicle fusion at neuromuscular junctions. The mechanism mirrors what botulinum toxin does at a structural level — disrupting the SNARE machinery that triggers acetylcholine release — but achieves this through peptide competition rather than enzymatic cleavage. SNAP-25 is a 206-residue membrane-associated protein; SNAP-8 mimics a small segment of it to compete for the assembly of the fusion complex.
Research Applications
The primary research interest in SNAP-8 is mechanistic: it provides a way to study neuromuscular transmission and vesicle exocytosis without the safety complications of using the botulinum toxin itself. Because it acts through competitive inhibition rather than irreversible protease activity, its effects are concentration-dependent and reversible within the experimental timescale — which gives researchers more control over dose-response characterization.
Dermatological research has also used SNAP-8 as a model compound for studying topical peptide delivery and its effects on facial muscle contraction patterns. Whether peptide applied to skin surface can reach neuromuscular junctions in sufficient concentration to produce measurable physiological effects is genuinely debated. Some ex vivo skin models and some small experimental measurements have shown signals, others have not. The question of penetration depth relative to target depth remains unsettled. SNAP-8 is a useful tool compound for investigating this penetration question directly.
Specifications
| Parameter | Value |
|---|---|
| Active compound | SNAP-8 (Acetyl Glutamyl Heptapeptide-3) |
| Antal | 10mg lyophilized powder |
| Renhed | ≥98% (class-level specification) |
| Molecular weight | 1075.2 Da |
| Target protein | SNAP-25 (synaptosomal-associated protein 25) |
| Mechanism | SNARE complex competitive inhibition |
| Form | Lyophilized powder |
| Independent testing | Selected lots tested by Janoshik Analytical; searchable at certapeptides.com/verify |
Opbevaring
Store at -20°C, away from light and moisture. Reconstitute in sterile water at the concentration needed for your assay. Reconstituted solution is stable at 4°C for up to 14 days. Not compatible with strong reducing agents, which can alter the acetyl group. For vesicle fusion assays, prepare fresh dilutions immediately before use.
How does SNAP-8 compare to botulinum toxin as a research tool?
Botulinum toxin cleaves SNARE proteins irreversibly through enzymatic activity, which makes dose-response experiments difficult once you are past the threshold. It also requires strict biohazard handling. SNAP-8 offers a reversible, concentration-dependent handle on the same pathway with far simpler logistics. The trade-off is potency — botulinum toxin is active at subnanomolar concentrations while SNAP-8 is effective in the micromolar range. For mechanistic studies of SNARE assembly kinetics, SNAP-8 is often the more tractable choice.
What in vitro models are appropriate for SNAP-8 research?
Liposome fusion assays using fluorescent lipid mixing are the standard for quantifying SNARE-mediated membrane fusion in a minimal reconstituted system. Neuronal cell cultures (PC12 cells or primary motor neurons) with catecholamine release readouts offer a more physiologically relevant model. Electrophysiological assays in cultured neuromuscular preparations allow direct measurement of miniature end-plate potential frequency changes. Each model has different artifacts to control for, so converging evidence from at least two systems strengthens mechanistic conclusions.
SNAP-8 is supplied for laboratory research. Not for human consumption. For research purposes only.
| Parameter | Værdi |
|---|---|
| Aktiv forbindelse | SNAP-8 (Acetyl Glutamyl Heptapeptide-3) |
| Mængde | 10mg lyofiliseret pulver |
| Renhed | ≥98% (specifikation på klasseniveau) |
| Molekylvægt | 1075.2 Da |
| Målprotein | SNAP-25 (synaptosomal-associated protein 25) |
| Mekanisme | kompetitiv hæmning af SNARE-komplekset |
| Form | Lyofiliseret pulver |
| Uafhængig testning | Udvalgte partier testet af Janoshik Analytical; søgbare på certapeptides.com/verify |
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
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Returpolitik →Produktinformation
Dette produkt er udelukkende beregnet til videnskabelig forskning og udvikling. Det er et kemisk stof, der ikke må anvendes som lægemiddel, medicin, aktivt stof eller ingrediens i noget produkt beregnet til konsum hos mennesker eller dyr. Forskere skal håndtere denne forbindelse i overensstemmelse med deres institutions biosikkerhedsretningslinjer. Må kun anvendes i korrekt udstyrede laboratoriemiljøer med passende personlige værnemidler.
Peptider i lyofiliseret (frysetørret) form sendes i forseglede glasvials med standardleveringsmetoder og kræver ikke køling under transport. Lyofiliserede peptider er meget stabile ved omgivelsestemperaturer i standardforsendelsens varighed (typiske transittider vises ved checkout). Efter modtagelse skal produktet hurtigt overføres til køleopbevaring (2–8°C).
Ofte stillede spørgsmål
Forskningspeptider leveres i lyofiliseret (frysetørret) form. Mængden af materiale er typisk kun få milligram — det kan fremstå som en meget tynd film eller en lille pellet i bunden af vialen, ofte næsten usynlig. Dette er helt normalt.
I modsætning til nogle leverandører, der tilsætter fyldstoffer (såsom Mannitol), leverer CertaPeptides rent peptid uden unødvendige tilsætningsstoffer.
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