VIP
VIP · Result: 99.142% · Measured content: 9.80 mg (98% of label) · Report Code: I7YDCQMYJIJ8 · Test Date: 2026-09-18 · Lab: Janoshik Analytical
View independent report #233643 ↗Cyclic and Neuropeptide Research Compounds SKU: CP-VIP
VIP
♢ Research use only Klasės lygmens specifikacija; atrinktos partijos tirtos Janoshik
✓ Janoshik Verified 99.142%VIP · Report #233643 ↗Free standard EU shipping on orders over €200
If a product doesn't match the specification on its published COA, contact us with your batch number: we investigate against the lot's report and replace any product that fails it, at no cost to you.
Contact us within 48 hours of delivery with photos of the outer box, inner packing, and any affected vials with labels legible. Confirmed transit damage is replaced at no cost to you.
Returns policy →Shipping estimate for EU
3–7 days most of the EU · 10–14 Nordics/Baltics. Dispatched within 1–2 business days. Check destination rates at checkout.
Full shipping informationMokslinių tyrimų klasės VIP. Klasės lygmens specifikacija ≥98%; atrinktos partijos testuojamos nepriklausomai. Liofilizuoti milteliai sandariame stikliniame flakone. Tik laboratoriniams tyrimams. Neskirta vartoti žmonėms.
Aprašymas
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide originally discovered in porcine intestine in 1970. The name describes the initial pharmacological observation — it is vasoactive and found in the gut — but underrepresents the peptide’s biology. VIP is now understood as a pleiotropic neuromodulator with roles in the immune system, circadian rhythm regulation, reproductive function, and multiple neural circuits. It is found throughout the nervous system and peripheral organs.
VIP signals through two GPCRs: VPAC1 and VPAC2 (previously VIP1R and VIP2R). VPAC1 is expressed broadly including in lymphocytes, lung, intestine, and liver. VPAC2 is more restricted, with prominent expression in T-cells, the suprachiasmatic nucleus (the circadian clock), and several brain regions. In research models, VPAC receptor activation elevates cAMP and is studied for the downstream effects characteristic of VIP signaling: smooth muscle relaxation (including bronchodilation and vasodilation), neurotrophin production, anti-inflammatory cytokine shifts, and inhibition of T-cell proliferation. VIP is one of the most potent endogenous anti-inflammatory peptides studied.
Research interest in VIP has focused on: inflammatory pathways (VIP shifts immunity toward anti-inflammatory Th2/Treg phenotypes in research models), pulmonary vascular biology (bronchodilation, vasodilation), and circadian biology (VIP neurons in the suprachiasmatic nucleus are required for circadian rhythm generation and synchronization).
Specifications
| Parameter | Value |
|---|---|
| Compound | Vasoactive Intestinal Peptide (VIP), 28 amino acids |
| Grynumas | ≥98% (class-level specification) |
| Format | Lyophilized powder |
| Reconstitution | Sterile water or saline |
| Laikymas | -20°C; 2-8°C after reconstitution, protect from light |
Laikymas
Store at -20°C and protect from light. Refrigerate at 2-8°C after reconstitution and use within 14 days. VIP is a relatively fragile peptide — minimize handling time and exposure to elevated temperature after reconstitution.
What are VIP’s main anti-inflammatory mechanisms?
In research models, VIP inhibits innate and adaptive immune responses through multiple mechanisms. It reduces macrophage and dendritic cell production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12) while increasing anti-inflammatory cytokines (IL-10). In T-cells, VIP inhibits Th1 and Th17 differentiation (pro-inflammatory phenotypes) and promotes Treg and Th2 differentiation (anti-inflammatory phenotypes). It also inhibits NK cell cytotoxicity and reduces neutrophil function. These broad anti-inflammatory effects make VIP one of the most immunomodulatory peptides studied and have driven research interest in VIP and its receptor pathways in autoimmune-disease models.
How does VIP regulate circadian rhythms?
VIP is the primary neurotransmitter of the suprachiasmatic nucleus (SCN), the brain’s master circadian clock. VIP neurons in the SCN synchronize individual cellular clocks within the nucleus and are essential for maintaining coherent circadian oscillations across the network of clock cells. VPAC2 receptors on SCN neurons receive VIP signals to synchronize their molecular clock cycles. VIP also helps the SCN respond to light signals that reset the clock daily. Mice lacking VIP or VPAC2 lose circadian behavioral rhythms, demonstrating VIP’s essential role in circadian timekeeping.
What biology is being studied with VIP in research?
VIP has been investigated in research on pulmonary vascular biology (where vasodilation and anti-proliferative effects on pulmonary vasculature are relevant), intestinal inflammation, and autoimmune-related immune pathways. Inhaled VIP has been examined in pulmonary models with mixed results. The short half-life of native VIP (minutes) is a challenge for systemic study, and modified longer-acting VIP analogues are being characterized. In research contexts, the immunological and circadian biology applications are particularly active areas.
VIP is supplied for research purposes only. Not for human consumption. Handle in compliance with institutional biosafety guidelines.
| Parametras | Reikšmė |
|---|---|
| Junginys | Vasoactive Intestinal Peptide (VIP), 28 aminorūgštys |
| Grynumas | ≥98% (klasės lygmens specifikacija) |
| Forma | Liofilizuoti milteliai |
| Rekonstitucija | Sterilus vanduo arba fiziologinis tirpalas |
| Laikymas | -20°C; 2-8°C po rekonstitucijos, saugoti nuo šviesos |
Follow the storage conditions on the product label and its published documentation. Handle only in an appropriately equipped laboratory.
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Šis produktas skirtas tik moksliniams tyrimams ir plėtrai. Tai cheminė medžiaga, kurios negalima naudoti kaip vaisto, vaistinio preparato, veikliosios medžiagos ar sudedamosios dalies jokiame produkte, skirtame žmonėms ar gyvūnams vartoti. Tyrėjai privalo tvarkyti šį junginį laikydamiesi savo institucijos biosaugos gairių. Naudokite tik tinkamai įrengtose laboratorijose su atitinkamomis asmeninėmis apsaugos priemonėmis.
Liofilizuotos (šaltyje džiovintos) formos peptidai siunčiami sandariai užsandarintuose stikliniuose flakonuose standartiniais pristatymo būdais ir transportavimo metu jų nereikia šaldyti. Liofilizuoti peptidai yra labai stabilūs aplinkos temperatūroje standartinio siuntimo trukmės metu (įprasti tranzito laikotarpiai nurodomi atsiskaitant). Gavę produktą, nedelsdami perkelkite jį laikyti šaldytuve (2–8°C).
Dažniausiai užduodami klausimai
Tyrimų peptidai tiekiami liofilizuotos (šaltyje džiovintos) formos. Medžiagos kiekis paprastai tesudaro vos kelis miligramus — flakono dugne jis atrodo kaip labai plona plėvelė ar maža granulė, dažnai beveik nematoma. Tai visiškai normalu.
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